2021 Sienna driving into the city at sunset


  • Both the Sienna and Odyssey have comparable driver-assistive safety features.
  • Only the Sienna comes standard on all grades with Blind Spot Monitor (BSM) with Rear Cross-Traffic Alert (RCTA), however.
  • Plus, you get an additional lower anchor position in the 2021 Sienna with the center third-row.

The newest advanced safety technologies can provide a welcomed reminder or correction from time-to-time. With advanced driver-assistive technology that comes in the Sienna and Odyssey, you can feel more confident during your drive.

Standard Safety Features

The 2021 Sienna comes standard with Toyota Safety Sense 2.0 (TSS 2.0) which includes a whole list of active safety features. You can expect a Pre-Collision System with Pedestrian Detection (PCS w/PD), Lane Departure Alert with Steering Assist (LDA w/SA), Lane Tracing Assist (LTA), Automatic High Beams (AHB), Full-Speed Range Dynamic Radar Cruise Control (DRCC), and Road Sign Assist (RSA).

The Odyssey's Honda Sensing Safety and Driver Assistive Technologies include similar features like the Collision Mitigation Braking System™ (CMBS™), Lane Keeping Assist System (LKAS), Lane Departure Warning (LDW), Adaptive Cruise Control with Low-Speed Follow (ACC), Auto High-Beam Headlights, and Traffic Sign Recognition System (TSR).

However, in a base-grade comparison, the Odyssey LX does not come standard with the Blind Spot Information System (BSI) with Cross Traffic Monitor while Blind Spot Monitor (BSM) with Rear Cross-Traffic Alert (RCTA) is standard on the all Siennas.

Additionally, the Sienna has notable passive safety features as well. The Sienna LE 8-Passenger has five LATCH positions which include Lower Anchors and Tethers for Children. Lower anchors are on all three second-row seats, and passenger-side and center third-row seats. The Odyssey has Lower Anchors (2nd-Row All, 3rd-Row Passenger-Side) and Tether Anchors (2nd-Row All, 3rd-Row All). You get the extra center third-row anchor with the Sienna.

Two 2021 Siennas parked side by side


  • The Sienna has several drive modes you can switch between depending on your driving needs.
  • While the Sienna has optional AWD, the Odyssey only has FWD available.
  • With an EPA-estimated 36/36/36 (city/highway/combined) MPG rating you can go father for less in the Sienna FWD.

Although a minivan offers a more sensible way to haul around lots of passengers, it can still be fun to drive. The Sienna has different driving modes and optional AWD to keep your adventures going.

All-Hybrid Performance

Depending on your drive, the Sienna has Normal, ECO, EV, and Sport modes. The Odyssey only has Snow Mode as an additional driving option.

While the Odyssey's Snow Mode may help to improve performance when it begins to flurry, the Sienna has available AWD on all trim levels. The Odyssey does not offer AWD. With four wheels gripping the road instead of two, you'll be better equipped to handle inclement weather.

Adding to its performance on the road, all Sienna models have a hybrid engine. The Sienna FWD has an EPA-estimated 36/36/36 (city/highway/combined) MPG rating and the AWD versions have an EPA-estimated 35/36/35 (city/highway/combined) MPG rating. The competition doesn't even come close with an EPA-estimated 19/28/22 (city/highway/combined) MPG rating across every engine option in the Odyssey lineup.

Interior of 2021 Sienna


  • The Sienna's super-long-slide feature allows for 25 inches of seat travel to do with as you please.
  • You also get more ways to listen with Android Auto™, Apple CarPlay®, and Amazon Alexa compatibility standard with the Sienna.
  • Whether you're in the driver's seat or third row, the Sienna has USB ports for everyone.

From connectivity options for everyone to spacious seating and other unique interior touches, the 2021 Sienna has it all.

Comfort and Convenience

With the super-long-slide feature, get easy access to third-row seating in the Sienna XLE 7-Passenger. Or, slide the second-row seat all the way back to get the kids from their car seats without having to strain to get them out. The Sienna’s 25 inches of seat travel also allows for versatility in sharing additional leg room or storage in the Sienna. The Odyssey has no such feature.

Beyond seating, the Sienna keeps everyone comfortable with standard three-zone automatic climate control with air filter, individual temperature settings for driver, front passenger and rear-seat passengers, and a separate rear digital control panel. Plus, four-zone automatic climate control is standard on the XLE and higher. Comparatively, the Odyssey comes standard with an Automatic Climate Control System. The Tri-Zone Automatic Climate Control System with 2nd-Row Controls, Humidity Control and Air Filtration is only available on the Odyssey EX or higher.

Once you're comfortable you can sit back and listen to some tunes, or turn on entertainment for the kids. When it comes to connectivity, you can expect hands-free phone capability and music streaming via Bluetooth® wireless technology and SiriusXM® with a 3-month All Access trial subscription standard on the Toyota Sienna. You also get Android Auto™, Apple CarPlay®, and Amazon Alexa compatibility on all grades. Looking at the Honda Odyssey, drivers get Bluetooth® HandsFreeLink® and Streaming Audio standard, but Apple CarPlay® and Android Auto™ Integration, and SiriusXM® Radio are only available on the higher-end Odyssey EX and higher.

On long road trips or short commutes to work, keep your devices fully charged with 7 USB ports across all three rows, which are standard in the Sienna. The Odyssey LX has one center console USB Charging Port and one center console USB Audio Interface. Even on the Odyssey Elite, which includes the most USB ports available for the Odyssey, there are only five.

Conclusion: Sienna vs. Odyssey

A matchup between the 2021 Sienna and the Odyssey shows strengths for each minivan, but the Toyota is a clear winner for several reasons. The Sienna offers drivers and families a spacious ride with great safety features, better fuel economy, and interior options that deliver a comfortable driving experience.

  • The Sienna is a fan favorite that was named the 2021 Best Buy Minivan by Kelley Blue Book®.
  • The Sienna comes standard with seven USB ports that let you charge your devices in all three rows of seating.
  • The super-long slide feature in the Sienna allows the seat to move up to 25 inches for extra leg room or cargo space.
  • The Sienna comes standard with more ways to listen, including Android Auto™, Apple CarPlay®, and Amazon Alexa compatibility.
  • Sienna comes with Normal, ECO, EV151, and Sport modes to adjust to your driving needs.
  • The Sienna comes standard with Blind Spot Monitor (BSM) with Rear Cross-Traffic Alert (RCTA).